Induction of GNE in Myofibers after Muscle Injury
نویسندگان
چکیده
منابع مشابه
Induction of GNE in myofibers after muscle injury.
OBJECTIVE The aim of the present study was to clarify the expression of uridine diphospho-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) protein and mRNA in damaged or regenerating myofibers. METHODS We investigated the muscle expression pattern of GNE protein by immunohistochemistry using a murine model involving intramuscular injection of cardiotoxin (CTX), and the express...
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BACKGROUND Mutations of the UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine-kinase (GNE)-gene are causally related to GNE myopathy. Yet, underlying pathomechanisms of muscle fibre damage have remained elusive. In sporadic inclusion body myositis (sIBM), the pro-inflammatory cell-stress mediators αB-crystallin and inducible nitric oxide synthase (iNOS) are crucial markers of the disease ...
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ژورنال
عنوان ژورنال: Pathobiology
سال: 2010
ISSN: 1015-2008,1423-0291
DOI: 10.1159/000292652